A Macintosh-based Expert System for LC/MS & MS/MS Analysis

Sherpa is designed to be a robust, easy to use aide-de-camp in the correlation and interpretation of LC/MS and MS/MS spectra to a known protein sequence or sequences. Native files from Sciex APIIII, Sciex 100/300, and Finnigan SSQ/TSQ electrospray mass spectrometers are currently supported. MS/MS files from other formats can be imported as tab-delimited text files. Sherpa is licenced for distribution by the University of Washington. A fully-featured demo and a new freeware lite version can be downloaded from the download page.

Sherpa was developed by Alex Taylor and Richard Johnson in Ken Walsh's Lab in the Biochemistry Department at the University of Washington in Seattle, WA.



- Online Sherpa User Guide

- Downloadable version for viewing offline: Sherpa3.3.1DocHTML.sea.hqx (244 Kb).


View a poster presented at the 1996 ABRF conference in San Francisco describing the program.

An article describing Sherpa can be found in Rapid Communications in Mass Spectrometry :
    Taylor, J.A., Walsh, K.A., Johnson, R.S. "Sherpa: A Macintosh-based expert system for the interpretation of ESI LC/MS and MS/MS of protein digests". Rapid Commun. Mass Spectrom. 10, 679-687 (1996).
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Last Updated May 1, 2004
J. Alex Taylor (